However, the measurement of sIL-2R is simple compared to the complex story behind this biomarker that has become so central to the study of immune-mediated disease. Why measure soluble interleukin-2 ...

This animation illustrates the conformational changes of IL-2 and the transition from a “closed” to “open” AB loop conformation (in red). (Image credit: Viviane De Paula) The signaling molecule ...

Interleukin-2 (IL-2) is a vital cytokine in adoptive cell therapy that plays an important part in the stimulation and growth of immune cells as well as Tumor-Infiltrating Lymphocytes (TIL), Chimeric ...

A new phase II clinical trial finds the drug ILT-101 (also known as aldesleukin or the brand name Proleukin®) is safe and beneficial for people with lupus. ILT-101 is a low-dose human recombinant ...

"Boosting the immune defense: Interleukin-2 promotes fate decisions in CD8 T cells for long- or short-term immune protection." ScienceDaily. www.sciencedaily.com / releases / 2022 / 02 / ...

How to Optimize Physicians’ Communication Skills in Cancer Care: Results of a Randomized Study Assessing the Usefulness of Posttraining Consolidation Workshops Purpose: This prospective, randomized, ...

Low dose interleukin 2 is being tested as an immunomodulatory approach in neurodegenerative diseases. It increases the number and activity of regulatory T cells (Tregs) that suppress inflammation. At ...

Excellent Outcome With Reduced Treatment in Infants With Nonmetastatic and Unresectable Neuroblastoma Without MYCN Amplification: Results of the Prospective INES 99.1 Median age at registration was ...

However, imbalances of IL-6 — too much or too little — can cause disease, even in the absence of infection. Excess IL-6 is central to the pathogenesis of inflammatory reactions like rheumatoid disease ...

A study in the journal Science Immunology now shows how two subsets of one type of immune cell — the CD8 T cell — develop to provide either short-term or long-term immune protection. The study focuses ...