Nature

Silencing L-selectin expression by siRNA attenuated metastasis of murine lymphoid neoplasm cell P388D1 to peripheral lymph nodes

You have full access to this article via your institution. Taken together, these results indicate that, similar to normal lymphocyte homing mechanisms, P388D1 cells transmigrate to lymph nodes by an L ...
Nature

N-acetylglucosamine-6-O-sulfotransferases 1 and 2 cooperatively control lymphocyte homing through L-selectin ligand biosynthesis in high endothelial venules

Lymphocyte homing is mediated by specific interactions between L-selectin on lymphocytes and sulfated carbohydrates restricted to high endothelial venules in lymph nodes. Here we generated mice ...
JSTOR Daily

Levels of L-Selectin (CD62L) on Human Leukocytes in Disseminated Cryptococcosis with and without Associated HIV-1 Infection

Patients with disseminated cryptococcosis typically have measurable levels of cryptococcal polysaccharide in serum samples but minimal leukocyte infiltration into infected tissues. In vitro data have ...
JSTOR Daily

L-Selectin-Mediated Leukocyte Tethering in Shear Flow Is Controlled by Multiple Contacts and Cytoskeletal Anchorage Facilitating Fast Rebinding Events

L-selectin-mediated tethers result in leukocyte rolling only above a threshold in shear. Here we present biophysical modeling based on recently published data from flow chamber experiments, which ...
News Medical

Roles of Selectins in the Immune System

Selectins are required for the trafficking of innate immune system cells, T lymphocytes and platelets. The absence of selectins or their ligands has severe health consequences, with recurrent ...