Figure 8: Regulation of ALDH3A1 and NECTIN4 by p53. Researchers Jessica J. Miciak, Lucy Petrova, Rhythm Sajwan, Aditya Pandya, Mikayla Deckard, Andrew J. Munoz, and Fred Bunz from the Sidney Kimmel ...

Researchers at The University of Texas MD Anderson Cancer Center have discovered that mutant KRAS and p53, the most frequently mutated genes in pancreatic cancer, interact through the CREB1 protein to ...

The protein p53, best known as the "guardian of the genome" for its role in preventing cancer, can affect blood vessels in ...

Researchers created a new kind of cancer drug that can grab a mutant protein while also carrying a second hit against the ...

All tissues are not equally sensitive to radiation. It has long been recognized that the well-known tumor suppressor protein and transcription factor p53 is linked to the degree of a tissue’s ...

“Our results provide unique insights into the mechanism of action of PG3 as a novel cancer therapeutic targeting p53 pathway-like tumor suppression” As highlighted in the abstract of this study, ...

Silencing of SLC35F2 gene influences the biologic behavior of human lung cancer cell line H1299. The effect of blocking the prosurvival AKT/P13K/mTOR and mutant KRAS–signaling pathways on chemotherapy ...

In a recent perspective published in the journal Cell Death and Differentiation, researchers in France, Germany, and Sweden discussed the unique mutational spectrum of the transformation-related ...

St. Jude Children's Research Hospital scientists have identified a promising combination approach to treat a rare but catastrophic pediatric brain cancer called atypical teratoid rhabdoid tumor (ATRT) ...